You have an outgoing, open and aggression in your personality. Your luck factor would favour you at critical times and would generally bail you out of negative situations.
The birth details of your sister would be required to analyse her chart, however as per your chart we can say that your presence would greatly enhance the well being of your sister and chances are, she could be on a quicker path of recovery.
With respect to your query of switching of jobs, currently you have a moderately positive time up to Jan 2023 and thereafter the time would be even better as per your chart, so can plan your efforts accordingly, as suitable.
Mesha lagna with the lagna lord Mars posited in the seventh house; Lord of third house retrograde Mercury posited in the fifth house conjunct Sun and Rahu; Retrograde Jupiter debilitated in the tenth house and exalted in the third house in Navamsha.
Retrograde Saturn posited in the twelfth house in the natal chart and in the own Kumbha Navamsha in the tenth house; Rahu Maha Dasha running with Jupiter Antar Dasha and Saturn Antar Dasha from Jan 2023 onwards.